A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity.
In a screen for genes that affect the metabolic response to high-fat diet (HFD), we selected one line of N-ethyl-N-nitrosourea (ENU)-mutagenized mice, Jll, with dominantly inherited resistance to diet-induced obesity (DIO).Mutant animals had dramatically reduced body weight and fat mass, and low basal insulin and glucose levels relative to unaffect